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Workshop #2 at the NSLS Users' Meeting

Anatomy of a Virus

Location: Bldg. 463, Biology, Lg Seminar Rm

Date: May 17, 2004

Organizers:
Marc Allaire, BNL (allaire@bnl.gov)
Paul Freimuth, BNL (freimuth@bnl.gov)

Description: Molecular structures of viruses near atomic resolution have made a dramatic impact in virology and understanding the role of the virion and its components in viral replication. These studies also revealed the associated-difficulties in obtaining the structure of large macromolecular assemblies. Structural studies of viruses were among the first applications of synchrotron radiation to macromolecular x-ray crystallography and the combination of crystal structure data with electron microscopy. At this workshop we will learn about the latest results on the structure/function relationships of virion and virion components in respect to the life cycle of multiple families of viruses. The main goal of the workshop is to understand the pitfalls of these structural studies. It is intended to be a forum of discussion to highlight the important requirements for the study of viral structure and the future needs in Structural Virology.

Schedule:

8:25 a.m. Introduction
8:30 a.m. Historical Perspective with Don Caspar
"Trials and Errors in Virus Visualization"
9:15 a.m. Denis Leclerc (Laval University)
Assembly of Hepatitis C Virus Core Protein
9:45 a.m. Michael Chapman (Florida State University)
Adeno-Associated Virus - Structural Studies of a Gene Therapy Vector
10:15 a.m. Break
10:45 a.m. Huilin Li (Brookhaven National Laboratory)
Genomic RNA Packaging in the Vesicular Stomatitis Virus
11:15 a.m. Stacy Benson (The Wistar Institute)
Structural Studies of the Lipid-Containing Bacteriophage PRD1
11:45 a.m. Michael Rossmann (Purdue University)
"Membranes and Motors: Where electron microscopy meets crystallography"
12:30 p.m. Lunch
1:30 p.m. Philip Dormitzer (Harvard Medical School)
Structural Rearrangements during Rotavirus Cell Entry
2:15 p.m. Wayne Hendrickson (Columbia University)
"Structural Biology of HIV Attachment and Entry into Cells"
3:00 p.m. Break
3:30 p.m. David Stuart (Oxford University)
"Motors and Membranes: Where crystallography meets electron microscopy"
4:15 p.m. John Johnson (The Scripps Research Institute)
Structure-Based Studies of Auto-Catalytic Chemistry in Virus Particles: Mechanisms and Purpose
5:00 p.m. Discussion: Future of Structural Virology
5:45 p.m. Conclusion