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Workshop #4 at the NSLS Users' Meeting

Pharmaceutical Applications of Synchrotron Radiation

Location: Bldg. 490, Medical Seminar Rm

Date: May 17, 2004

Organizers:
Evgenyi Shalaev, Pfizer Inc. (evgenyi_y_shalaev@groton.pfizer.com
Raj G. Suryanarayanan, College of Pharmacy (surya001@tc.umn.edu)
Peter Stephens, SUNY Stony Brook (pstephens@notes.cc.sunysb.edu)

Description: X-ray diffractometry (XRD) finds widespread application in characterization of pharmaceutical materials. Conventional XRD technique has limitations in sensitivity and time resolution. These can be overcome with the use of synchrotron radiation which is significantly more intense than a conventional X-ray tube source hence providing a superior signal/noise ratio. The use of synchrotron radiation has lead to developments in traditional areas such as phase quantification, strain measurements, and also opened up possibilities for dynamic and time resolved investigations of phase changes, solid state reactions, the solution and refinement of crystal structures from powder data, and analysis of the local structure of disordered and partially ordered solids. In addition, the workshop highlights hot topics in dynamics and structure of amorphous materials as viewed by pharmaceutical science, and features a round table discussion to bring collaboration between synchrotron experts and pharmaceutical scientists to a new level.

Schedule:

9:00 a.m. Raj G. Suryanarayanan & Evgenyi Shalaev
Opening Remarks
Crystalline phases
9:10 a.m. Peter W. Stephens
"Pharmaceutical applications of synchrotron radiation"
9:40 a.m. W.I.F. David
In-situ dehydration studies of pharmaceutical compounds using synchrotron radiation
10:10 a.m. Ken Shankland
Optimising your chances of solving a drug structure (accurately) from powder diffraction data
10:40 a.m. Break
Amorphous and other disordered materials
11:00 a.m. M.J. Pikal
Amorphous pharmaceuticals: what we know and do not know about their dynamics and stability
11:30 a.m. E.Y. Shalaev
The concept of “structure” in amorphous solids from the perspective of the pharmaceutical sciences
12:00 noon Lunch
Amorphous and other disordered materials (continuation)
1:00 p.m. Raj G. Suryanarayanan
Evaluation of the degree of crystallinity of pharmaceuticals
1:30 p.m. Satyendra Kumar
Self-assembled structures in pharmaceutically-relevant systems
2:00 p.m. Heinz Amenitsch
Characterization of Pharmaceutical Nanophase Formulations by Synchrotron SWAXS
2:30 p.m. Break
Round table
3:00 p.m. Moderator: Bruno Hancock
"Collaboration between NSLS and pharmaceutical scientists: status, issues, and plans"
4:00 p.m. Adjourn