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Workshop #5 at the NSLS Users' Meeting

Application of Small Angle X-Ray Scattering to Biological Structures

Location: Bldg. 510, Physics, Large Seminar Room

Date: Wednesday, May 25, 2005

Organizers:
Lin Yang (BNL, NSLS) (lyang@bnl.gov)

Description: Small Angle X-ray Scattering (SAXS) provides direct structural characterization at length scales from a few nm to a micron. Though this characterization of biological samples is often of low resolution, when combined with complementary techniques, SAXS becomes a very powerful tool. This workshop aims at promoting the use of SAXS for the study of biomolecules and biomaterials by demonstrating its application to a wide range of biological structures of increasing complexity, from macromolecules to molecular assemblies to biological tissues. Participants are encouraged to bring slides to show their results, make comments/suggestions during the discussion session.

Schedule:

9:00 a.m. Welcome
9:05 a.m. Dmitri Svergun, EMBL
"Small-angle X-ray Scattering Studies of the Structure of Biological Macromolecules in Solution"
9:45 a.m.  Lee Makowski, ANL
"Estimating Protein Fold Using Wide-Angle Solution Scattering Data"
10:25 a.m. Break
10:55 a.m. Annette Tardieu, BPSF
"Bio-Macromolecular Interactions in Solution and Crystallization"
11:35 a.m. Jack Johnson, Scripps
"Small Angle Scattering Studies of Cooperativity in the Dynamic Conformational Reorganization of a 420 Subunit Icosahedral Capsid"
12:15 p.m. Lunch
1:30 p.m. Ben Hsiao, SBU
"Biomineralization of Bone by Simultaneous X-ray Scattering/Diffraction Studies"
2:10 p.m. Leepo Yu, NIH
"Conformation and Helical Order of the Myosin Filaments in Skeletal Muscle Cells"
2:50 p.m. Michael Sacks, University of Pittsburgh
"Molecular Orientation of Collagen in Intact Planar Connective Tissues under Biaxial Stretch"
3:30 p.m. Break
4:00 p.m. Discussion
5:00 p.m. Adjourn